icobrain ms

icobrain ms helps physicians assess (sub)clinical disease activity in patients with multiple sclerosis.

icobrain ms allows for the objective assessment of lesion dissemination in space and time by:
- Quantifying and tracking FLAIR WM hyperintensities and T1 WM hypointensities

icobrain ms provides measures of brain volume changes by:
- Tracking annualized brain volume changes for whole brain and gray matter
- Comparing brain volumes and volume changes to an age-and gender-matched reference population.
Information source: Vendor
Last updated: March 17, 2024

General Information

Product name icobrain ms
Company icometrix
Subspeciality Neuro
Modality MR
Disease targeted Multiple sclerosis
Key-features White matter abnormality quantification, brain volume change, report generation
Suggested use During: perception aid (prompting all abnormalities/results/heatmaps), report suggestion

Technical Specifications

Data characteristics
Population multiple sclerosis patients
Input For MRI: 3D T1 weighted image and 3D FLAIR
Input format DICOM
Output Color-coded segmentation overlays, concise reports with reference statistics, pre-populated radiological reporting template
Output format DICOM
Integration Integration in standard reading environment (PACS), Integration RIS (Radiological Information System), Integration via AI marketplace or distribution platform
Deployment Cloud-based
Trigger for analysis Automatically, right after the image acquisition, On demand, triggered by a user through e.g. a button click, image upload, etc.
Processing time > 10 minutes


Certified, Class IIa , MDR
FDA 510(k) cleared , Class II
Intended Use Statements
Intended use (according to CE) icobrain mr is intended for automatic labeling, visualization and volumetric quantification of segmentable brain structures from a set of MR images. This software is intended to automate the current manual process of identifying, labeling and quantifying the volume of segmentable brain structures identified on MR images. icobrain mr consists of two distinct image processing pipelines: icobrain mr cross and icobrain mr long. icobrain mr cross is intended to provide volumes from images acquired at a single timepoint. icobrain mr long is intended to provide changes in volumes between two images that were acquired on the same scanner, with the same image acquisition protocol and with same contrast at two different timepoints. The results of icobrain mr cross cannot be compared with the results of icobrain mr long.


Market presence
On market since 2016
Distribution channels Blackford, GE Edison marketplace, Nuance PIN, Calantic
Countries present (clinical, non-research use) 23
Paying clinical customers (institutes) >100
Research/test users (institutes) >300
Pricing model Subscription
Based on Number of analyses


Peer reviewed papers on performance

  • Reliable measurements of brain atrophy in individual patients with multiple sclerosis (read)

  • Two Time Point MS Lesion Segmentation in Brain MRI: An Expectation-Maximization Framework (read)

  • icobrain ms 5.1: Combining unsupervised and supervised approaches for improving the detection of multiple sclerosis lesions (read)

Non-peer reviewed papers on performance
Other relevant papers

  • A Novel Digital Care Management Platform to Monitor Clinical and Subclinical Disease Activity in Multiple Sclerosis (read)